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2 edition of Measurement of pulmonary function in the evaluation of toxic lesions in the rat. found in the catalog.

Measurement of pulmonary function in the evaluation of toxic lesions in the rat.

Eric T. Whalley

Measurement of pulmonary function in the evaluation of toxic lesions in the rat.

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Published by The Author in Bradford .
Written in English


Edition Notes

M.Sc. dissertation. Typescript.

SeriesDissertations
ID Numbers
Open LibraryOL13657741M

bromoform and dibromochloromethane (NTP , a); this is likely due to central nervous system depression rather than impaired lung function. Bromoform. No studies were located regarding respiratory effects in humans after oral exposure to bromoform. NTP (a) examined the respiratory tract of rats and mice receiving gavage doses of. Thus cadmium-induced hypofunction of the testes, and subsequent loss of circulating testosterone, appears to be a critical aspect in cadmium induction of tumors in the rat testes. The following study demonstrates that estradiol (estrogen) causes a more rapid uptake of cadmium by the liver and also an enhanced induction of metallothionein (MT. S Shofer, C Badea, S Auerbach, D Schwartz, GA Johnson, A microCT-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice, Experimental Lung Research –, PMCID: PMC James F. Fries is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.


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Measurement of pulmonary function in the evaluation of toxic lesions in the rat. by Eric T. Whalley Download PDF EPUB FB2

In the evaluation of the effects of disease, chemical exposure, toxins, pollutants, and drugs, measurement of pulmonary function in animals can help discover, localize, and assess the magnitude of lesions in the lung.

The use of a particular lung function test or tests may be best for evaluating different types of lesions. The following section Cited by: 1.

HUMAN and animal data indicate that exposure to nitrogen dioxide (NO2) can produce a variety of toxicological responses of varying degrees of severity depending on the concentration and duration of exposure and on the sensitivity of the population being exposed.

Because NO2 is a gas, the primary route of exposure is via inhalation, making the lung the primary target organ. Adaptation of pulmonary function tests to animals has led to the comparison of human and animal data, generally providing more robust conclusions compared to data from single species.

Recent molecular measurements have brought home how closely tied many of these diseases are to specific protein changes. A full range of scientific evidence, extending from the molecular level to whole populations, supports the conclusion that secondhand smoke causes disease.

The scope of this evidence is enormous, and encompasses not only the literature on secondhand smoke but also relevant findings on active smoking and on the toxicity of individual tobacco smoke components. The. Under the authority of the Federal Advisory Committee Act (P.L.

) ofthe National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances has been established to identify, review, and interpret relevant toxicologic and other scientific data and develop acute exposure guideline levels (AEGLs) for high-priority, acutely toxic chemicals. Unfortunately, this book can't be printed from the OpenBook.

If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF. These findings suggested that rat blood clots earlier than human blood, which is in agreement with well-known results based on standard hematologic tests.

Evaluation of the Effects of Nicotinamide on the Bleomycin-induced Pulmonary Fibrosis in Rat Article (PDF Available) October with Reads How we measure 'reads'. Pulmonary manifestations, most commonly spontaneous pneumothorax, were the primary events leading to the diagnosis in % of cases.

Nearly 55% of the subjects were being treated with a progesterone derivative. An obstructive pattern on pulmonary function testing was observed in % of the subjects, whereas % had normal spirometric results. Functional changes Measurement of respiratory ASPECTS OF TOXICITY EVALUATION Introduction Toxicology is concerned both with the nature and mechanisms of toxic lesions and the quantitative evaluation of the spectrum of biological changes produced by exposure to chemicals.

Every chemical is toxic under certain conditions of. Pulmonary function study disclosed a restrictive abnormality (the vital capacity was 61 percent of predicted normal), with a diffusing capacity (DL co) of Other new tests included a blood level for the measurement of phthalic acid derivatives, namely phthalic anhydride, a decomposition product of PVC, which measured ng/ml, which is Cited by:   Pulmonary arterial hypertension Measurement of pulmonary function in the evaluation of toxic lesions in the rat.

book is a chronic and progressive disease leading to right heart failure and ultimately death if untreated. The first classification of PH was proposed in Inthe fourth World Symposium on PH held in Dana Point (California, USA) revised previous classifications.

Currently, PH is devided into five by: Summary of histological changes observed in rats exposed to ammonia for 6 weeks34 Table Incidence of pulmonary lesions in rats inoculated withM pulmonis and exposed to ammonia (7 days later for days) 41 Table Mortality in P.

multocida-infected mice exposed to ammonia for 8 or hours. 42 Table @article{osti_, title = {Effects of ozone on the defense to a respiratory Listeria monocytogenes infection in the rat. Suppression of macrophage function and cellular immunity and aggravation of histopathology in lung and liver during infection}, author = {Van Loveren, H and Rombout, P J and Wagenaar, S S and Walvoort, H C and Vos, J G}, abstractNote = {We.

Scott Adzick, MD, MMM, FACS, FAAP, is Surgeon-in-Chief of Children's Hospital of Philadelphia and the founder and Director of the Center for Fetal Diagnosis and Treatment. Patient Ratings: This provider currently has no ratings.

Adzick is the C. Everett Koop Professor of Pediatric Surgery at CHOP and the founder and Director of the. Additionally, in pulmonary and RV pathologies, the measurement of pulmonary acceleration time, which has been used extensively in humans as a measure of pulmonary pressure, has been validated in mice.

On the Vevothere is a noncontrast power Doppler mode, which provides information on vascularity that has mostly been used for oncology or Cited by:   The abnormality of respiratory muscle function in patients with chronic obstructive pulmonary disease (COPD) is multifaceted.

Because the involvement illustrates several pathophysiological principles, COPD serves as a suitable introduction for a discussion of respiratory muscle involvement in other disease by: INTRODUCTION. Pulmonary edema is defined as an abnormal accumulation of fluid in the extravascular compartments of the lung.

The relative amounts of intravascular and extravascular fluid in the lung are mostly controlled by the permeability of the capillary membrane as well as the oncotic pressure (, 1).This relation is described by the Starling equation, which is used to Cited by: Chronic obstructive pulmonary disease (COPD) severely restricts air flow into or out of the lungs.

Bronchitis. Mark Wick is a Pathologist in Charlottesville, VA. Find Dr. Wick's phone number, address, insurance information and more.

Identifying and Controlling Pulmonary Toxicants Box 3-A-General Principles of Toxicology To evaluate the toxic nature of a substance, including its pulmonary toxicity, scientists have developed several general criteria for consideration, including: Nature of the Toxic Substance.

International classification of rodent tumours. Part 1: The rat. Digestive system: Mohr, U. Book: International classification of rodent tumours. @article{osti_, title = {The pathological anatomy of acute experimental baryllium poisoning peripheral blood changes resulting from intravenous administration of beryllium sulphate}, author = {Scott, J.

E.}, abstractNote = {The lesions produced in the organs following a single intravenous administration of hydrated beryllium sulfate are described. Chapter 10 - Respiratory System STRUCTURE AND FUNCTION.

Morton Lippmann. The respiratory system extends from the breathing zone just outside of the nose and mouth through the conductive airways in the head and thorax to the alveoli, where respiratory gas exchange takes place between the alveoli and the capillary blood flowing around them.

Full text of "Pulmonary Tuberculosis Fourth Edition" See other formats. Liver function tests should be obtained at base- ing, and serum creatinine measurement should be performed at line and, if there is underlying liver disease, at monthly intervals. baseline. Assessments of renal function, and questioning regard.

Medial mucoid lesions of the pulmonary artery in cystic fibrosis, pulmonary hypertension, and other disorders. Lab Invest ;– PubMed Google ScholarCited by: 5. Despite current developments in pulmonary cancer aetiology, diagnosis, and treatment, pulmonary cancer remains the most frequently found cancer globally (% of complete instances) and the major cause of cancer mortality (% of complete cancer fatalities) in both women and men.

Current statistics show that the cancer incidence rate will. Proc. SPIEEndoscopic Microscopy XIII, (2 May ); doi: /   In MS lesions, there is a weak, but significant correlation between the number of Class I MHC restricted CD8+ T-lymphocytes and the extent of acute axonal injury (Bitsch et al., ).

This correlation was not found for total T-cells or CD4+ T-cells. Neurons and axons may express Class I MHC molecules in MS lesions (Hoftberger et al., )/5. More recently the lesions induced by beta-beta′-iminodipropionitrile, methyl iodide and methyl methacrylate in the rat nasal cavity have been mapped in three-dimensions to better visualize the intranasal distribution of these alteration and to further understand the possible roles of local bioactivation and dosimetry in the formation of these Cited by: P Environmental Epidemiology: The Importance of Exposure Assessment.

Proceedings of the Symposium on Exposure Measurement and Evaluation Methods for Epidemiology Held at Chicago, Illinois September(U.S.) Health Effects Research Lab.

Research Triangle Park, NC Prepared for American Chemical Society, Washington, DC Dec. Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

Drug-induced liver injury is a cause of acute and chronic liver disease. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.

Certain medicinal agents, when taken in overdoses and sometimes even Specialty: Gastroenterology. Pulmonary Hypertension Primary Pulmonary Hypertension Pulmonary Vascular Martinez-Cabruja R () Pulmonary vascular lesions in the toxic oil syndrome in Spain. Thorax – PubMed Google Scholar.

Wagenvoort CA () Lung biopsy specimens in the evaluation of pulmonary vascular disease. Chest – PubMed Google. Date Title Author(s) Ben. Journal Measurement uncertainties of size, shape and surface 1 measurements using transmission electron microscopy of near-2 monodisperse, near-spherical nanoparticles Pieter-Jan De Temmermann et al 26 Research Paper Semi-automatic size measurement of primary particles in aggregated.

Arenz A, Kelin M, Flehe K, et al. Occurrence of neurotoxic 4'-O-methylpyridoxine in ginkgo biloba leaves, ginkgo medications and Japanese ginkgo food. Laboratory Evaluation Other helpful and objective data obtained during this phase of the evaluation include the results of blood chemistries, hemoglobin, chest x-ray, pulmonary function tests.

Optical coherence tomography for the detection, diagnosis, and monitoring of pulmonary disease and thoracic malignancies (Conference Presentation) Melissa J. Suter Proc. SPIE17th International Photodynamic Association World Congress, I (14 August ); doi: /   In its evaluation of PAHs as ambient air pollutants inWHO expressed a unit cancer risk as a function of the concentration of B[a]P taken as a marker of the PAH mixture.

Use of the same unit risk factor for indoor air implies that B[a]P represents the same proportion of carcinogenic activity of the PAH mixture as in the occupational. Velocity-encoded cine MRI in the evaluation of left ventricular diastolic function: measurement of mitral valve and pulmonary vein flow velocities and flow volume across the mitral valve.

Am Heart J. Apr; (4) PMID:. Gallium, a group IIIa metal, is known to interact with hydroxyapatite as well as the cellular components of bone. In recent studies we have found gallium to be a potent inhibitor of bone resorption that is clinically effective in controlling cancer-related hypercalcemia as well as the accelerated bone resorption associated with bone metastases.Hartiala JJ, Mostbeck GH, Foster E, Fujita N, Dulce MC, Chazouilleres AF, Higgins CB.

Velocity-encoded cine MRI in the evaluation of left ventricular diastolic function: measurement of mitral valve and pulmonary vein flow velocities and flow volume across the mitral valve. Am Heart J. Apr; (4)Pulmonary edema and poor oxygenation in these cases will not respond to atropine and should be treated as a case of acute respira-tory distress syndrome.

• Children under 12 years: mg/kg body weight, repeated every 15 minutes until File Size: KB.